Mupirocin Side Effects, Dosage
Mupirocin:Mupirocin comes in an balm that is applied to the skin. Mupirocin usually is applied three times a day for 1 to 2 weeks. Follow the guidances on your instruction label delicately, and ask your doctor or pharmacologist to explain any part you do not understand. Use mupirocin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
The instruction in this database is contemplated to supplement, not supplant for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, orientations, precautions, drug communications or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, convenient or effective for you or anyone else. A healthcare specialist should be consulted before taking any drug, reversing any diet or commencing or discontinuing any course of employment.
Mupirocin is an penicillin that is used topically (on the skin) for the medication of impetigo, a bacterial malady of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus and Streptococcus pyogenes. It also is used intranasally (inside the nose) by patients and some communities who work in healthcare centers to eliminate methicillin-resistant Staphylococcus aureus (MRSA) that have conquered the inside of the nose.
Unlike most other penicillin that act on either bacterial DNA or the walls of bacteria, mupirocin blocks the activity of an incentive called isoleucyl-tRNA synthetase within the bacteria. This enzyme is necessary in order for the pathogens to make proteins. Without the ability to make proteins, the pathogens die. Because of its unique mechanism of action, there is little chance that bacteria will have become resistant to mupirocin because of disclosure to other antibiotics.
Mupirocin topical cream was approved by the FDA in December, 1987. The intranasal form was approved in October 1995.
What are the uses of mupirocin?
- Mupirocin is a drug used for the treatment of impetigo and infections of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus, or Streptococcus pyogenes.
- Mupirocin is not recommended for use on the skin in serious burns because more of the inactive ingredient used for the ointment, polyethylene glycol (Miralax), may be absorbed and can damage the kidneys.
- The nasal ointment is used for the elimination of multi-drug resistant nasal Staphylococcus aureus infection in people who are colonized by Staphylococcus aureus. Mupirocin also may be used for secondary infections as determined by your doctor.
Mupirocin Ointment Uses
For the treatment of impetigo, a small volume of the ointment is administered to the affected area, usually three times daily (every 8 hours). The area may be covered with a sterile gauze stuffing. If there is no development in 3-5 days the doctor should be telephone to re-examine the infected area.
For other coating infections, the cream is applied to the impressed area 3 times a day for 10 days, and the doctor should be contacted as well if there is no development after 3-5 days.
When mupirocin is used for treating intranasal Staphylococcus aureus that are resistant to other penicillin, patients who are age 12 years and older compel the application of about half of the salve from a single-use tube of salve into one nostril and the alternative half into the other nostril. This treatment is repeated twice daily for 5 days. Currently, there is not enough instruction to recommend use of mupirocin for the treatment of intranasal Staphylococcus aureus in youths younger than 12 years of age.
Mupirocin Side Effects
There are no known drug interactions with mupirocin; however, it should not be used at the same time with other drugs that are applied inside the nose.
- tell your doctor and pharmacist if you are allergic to mupirocin or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially chloramphenicol (Chloromycetin).
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using mupirocin, call your doctor.
What should I do if I forget a dose?
Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.
- burning, stinging, pain, itching, or rash
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
Is mupirocin safe to take if I’m pregnant or breastfeeding?
- There are no adequate studies of mupirocin in pregnant women; however, studies in animals suggest no important effects on the fetus. Mupirocin, therefore, can be used in pregnancy if the physician feels that it is necessary.
- There is no information on the safety of mupirocin in nursing infants. It is unknown if any of the small amount of mupirocin that is absorbed from the skin into the blood of the mother concentrates in breast milk. It is advisable, therefore, not to nurse while using mupirocin.
Mupirocin Ointment Usp 2
Mupirocin is a prescription drug. It comes as a topical ointment, topical cream, and nasal ointment.
Mupirocin topical ointment is available as the brand-name drug Centany. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.
Mupirocin topical ointment may be used as part of a combination therapy. This means you may need to use it with other medications.
- Contact warning: Be careful not to get this drug in your eyes. If it comes into contact with your eyes, rinse your eyes well with water. Don’t use this form of the drug inside your nose. It can cause stinging or drying.
- Allergic reactions warning: If you have an allergic reaction or severe irritation on your skin where you apply the ointment, stop using this drug and call your doctor. Symptoms of an allergic reaction include trouble breathing or swallowing, shortness of breath, swelling of your throat or tongue, itching, or a body rash. Your doctor may give you a different treatment for your infection.
- Length of treatment warning: Using this drug for a long time can cause microscopic organisms, such as bacteria or fungi, to overgrow. You should only use this drug for as long as your doctor recommends.
- Antibiotic-associated diarrhea warning: Almost all antibiotics, including mupirocin, can cause diarrhea due to an infection. This infection can cause mild diarrhea or severe inflammation of your colon. Severe reactions can be fatal (cause death). Tell your doctor if you have diarrhea. If you have this infection, you’ll need to stop using mupirocin and get treatment.
Mupirocin topical ointment is used for short-term treatment. It comes with serious risks if you don’t use it as prescribed.
If you stop using the drug suddenly or don’t use it at all: Your infection may not improve, and it may get worse.
If you miss doses or don’t use the drug on schedule: Your medication may not work as well or may stop working completely. The bacteria that this drug is treating may also develop resistance. This means that your medication will no longer work to kill the bacteria. For this drug to work well, a certain amount needs to be at the site of infection at all times.
If you use too much: The bacteria this drug is treating may develop resistance. This means that your medication will no longer work to kill the bacteria. If you think you’ve used too much of this drug, call your doctor.
What to do if you miss a dose: Apply your dose as soon as you remember. If you remember just a few hours before your next scheduled dose, apply only one dose.
How to tell if the drug is working: Your infection should start to get better within three to five days of using this drug.
What do you use mupirocin ointment for?
Mupirocin is an antibiotic that prevents bacteria from growing on your skin. Mupirocin topical (for use on the skin) is used to treat skin infections such as impetigo (IM-pe-TYE-go) or a “Staph” infection of the skin. Mupirocin topical may also be used for purposes not listed in this medication guide.
What bacteria does mupirocin kill?
Mupirocin works to kill the bacteria that are causing your infection. These include strains of Staphylococcus aureus and Streptococcus pyogenes. Mupirocin stops the bacteria from multiplying.